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Tuesday, May 5, 2020 | History

3 edition of Cyclooxygenase and Lipoxygenase Modulators in Lung Reactivity (Progress in Biochemical Pharmacology, Vol 20) found in the catalog.

Cyclooxygenase and Lipoxygenase Modulators in Lung Reactivity (Progress in Biochemical Pharmacology, Vol 20)

by Bert Ferruccio

  • 83 Want to read
  • 8 Currently reading

Published by S. Karger AG (Switzerland) .
Written in English

    Subjects:
  • Pharmacology,
  • Pharmacodynamics,
  • Medical / Nursing

  • The Physical Object
    FormatHardcover
    Number of Pages146
    ID Numbers
    Open LibraryOL12929593M
    ISBN 103805539746
    ISBN 109783805539746

    We exposed rabbits to phosgene (1, ppm/min), killed the animals 30 min later, and then perfused the lungs with a saline buffer for 90 min. Phosgene markedly increased lung weight gain, did not appear to increase the synthesis of cyclooxygenase metabolites, but increased fold the synthesis of lipoxygenase products.   The 2 hemiketal (HK) eicosanoids HKD 2 and HKE 2 are the major products of the biosynthetic crossover of the 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) pathways. HKs result from the rearrangement of a di-endoperoxide intermediate formed in the COXdependent oxygenation of 5S-hydroxyeicosatetraenoic acid (5S-HETE).We analyzed HK biosynthesis in human .

    Aspirin is not only one of the best-documented medicines in theworld, but also one of the most frequently used drugs of all times. Inaddition to its role as an analgesic, aspirin is being increasinglyused in the prophylaxis of ischemic heart disease and strokes. Theprevalence of aspirin intolerance is around 5 to 6%. Up to 20% of theasthmatic population is sensitive to aspirin and other. Arachidonic acid is then metabolized by cyclooxygenase (COX) and 5-lipoxygenase, resulting in the synthesis of prostaglandins and leukotrienes, respectively. These intracellular messengers play an important role in the regulation of signal transduction implicated in pain and inflammatory responses.

    Background Arachidonic acid is metabolized through three major metabolic pathways, the cyclooxygenase, lipoxygenase and CYP enzyme systems. Unlike cyclooxygenase and lipoxygenases, the role of CYP epoxygenases in monocyte/macrophage-mediated responses is not known. Methodology/Principal Findings When transfected in vitro, CYP2J2 is an efficient activator of . @article{osti_, title = {Oral gold compound auranofin triggers arachidonate release and cyclooxygenase metabolism in the alveolar macrophage}, author = {Peters-Golden, M and Shelly, C}, abstractNote = {We examined the effect of in vitro incubation with the oral gold compound auranofin (AF) on arachidonic acid (AA) release and metabolism by rat alveolar macrophages (AMs).


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Cyclooxygenase and Lipoxygenase Modulators in Lung Reactivity (Progress in Biochemical Pharmacology, Vol 20) by Bert Ferruccio Download PDF EPUB FB2

Cyclooxygenase and Lipoxygenase Modulators in Lung Reactivity (Progress in Biochemical Pharmacology, Vol. 20) Hardcover – March 8, by B. Ferruccio (Editor), S. Hurd (Editor), R. Johnsson Hegyeli (Editor), R. Paoletti (Series Editor) & 1 moreFormat: Hardcover.

Prog Biochem Pharmacol. ; Cyclooxygenase and lipoxygenase modulators in lung reactivity. U.S.-Italy symposium, Milan, April US-Italy Symposium on Cyclooxygenase and Lipoxygenase Modulators in Lung Reactivity ( Milan, Italy) Cyclooxygenase and lipoxygenase modulators in lung reactivity.

Basel ; New York: Karger, (OCoLC) Material Type: Conference publication, Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors.

The Lewis lung carcinoma was used as a model of both primary and metastatic disease to assess the ability of cyclooxygenase inhibitors (mefenamic acid, diflunisal, sulindac, and indomethacin), the collagenase inhibitor minocycline, and the lipoxygenase inhibitor phenidone to act as modulators of cytotoxic cancer by:   Cyclooxygenases.

Cyclooxygenase (COX) which has two isoforms, COX-1 and COX-2 is the enzyme that catalyzes the rate-limiting step in prostaglandin synthesis, converting arachidonic acid into prostaglandin H 2, which is then further metabolized to prostaglandin E2 (PGE 2), PGF 2α, PGD 2 and other eicosanoids [5, 6].COX-1 is constitutively expressed in many tissues and plays a role in Cited by: The Role of Cyclooxygenase and Lipoxygenase Mediators in Oxidant-induced Lung Injury Article (PDF Available) in The American review of respiratory disease (6) July with 35 Reads.

Cancer initiation and progression are multistep events that require cell proliferation, migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and ultimately secondary growth. Tumor cell functions at both primary or secondary sites are controlled by many different factors, including growth factors and their receptors, chemokines, nuclear receptors, cell.

They reported that the highest levels of PGs were produced by cell lines from non-small-cell lung cancer. Teicher et a have used cyclooxygenase inhibitors (mefenamic acid, diflunisal, sulindac, and indomethacin) and the lipoxygenase inhibitor phenidone as modulators of cytotoxic therapies in Lewis lung cancer.

The 12(S)-lipoxygenase is very similar in many respects to lipoxygenase (LO) in terms of its substrate specificity and capability of forming both HpETE and HpETE from AA.

The 12(S)-lipoxygenase has approximately 65% identity in primary structure to that of. the cascade, including the cyclooxygenase, lipoxygenase, and epoxygenase pathways. In each case, these pathways are named after the enzyme(s) that catalyzes the first committed step.

The prostanoids, which include the prostaglandins and thromboxanes, are formed via the cyclooxygenase pathway. The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury.

Journal of Neurochemistry(4), DOI: /jx. lipoxygenase and cyclooxygenase 1 and 2 by ML reduces licofelone (ML), an inhibitor of COX-1, COX-2 and 5- joint destruction in adjuvant arthritis.

J Rheumatol ; Substantial evidence supports a functional role for cyclooxygenase‐ and lipoxygenase‐catalyzed arachidonic and linoleic acid metabolism in cancer development. ase and lipoxygenase in modulating the process of ischemic renal injury.

MATERIALS AND METHODS: This is a litera- An insight into the role of cyclooxygenase and lipooxygenase pathway in renal ischeia in proteins, and DNA leading to apoptotic cell death Further, decreased antioxidant enzyme.

Book reviews Book reviews Books reviewed in this article: The Dimensions of Clinical Allergy, by R. Bookman. Cyclooxygenase and Lipoxygenase Modulators in Lung Reactivity. by F. Berti, S. Hurd and R.J. Hegyeli Asthma and Bronchial Hyperreactivity, Progress in Respiration Research, Vol Prostaglandin (PG) G/H synthase, most commonly referred to as cyclooxygenase (COX, (5Z,8Z,11Z,14Z)-icosa-5,8,11,tetraenoate,hydrogen-donor: oxygen oxidoreductase) activity, catalyses the formation of PGG 2 from arachidonic eroxidase activity inherent in the enzyme catalyses the formation of PGH 2 from PGG -1 and -2 can be nonselectively inhibited by ibuprofen.

Author(s): Berti,F(Ferruccio); Hurd,S(Suzanne); Hegyeli,Ruth Johnsson,; US-Italy Symposium on Cyclooxygenase and Lipoxygenase Modulators in Lung Reactivity,( Milan, Italy) Title(s): Cyclooxygenase and lipoxygenase modulators in lung reactivity/ US-Italy Symposium on Cyclooxygenase and Lipoxygenase Modulators in Lung Reactivity, Milan, April.

Cyclooxygenase expression. Cycloxygenase-1 was first purified from bovine vesicular glands in (Miyamoto et al., ).COX-1 is constitutively expressed in many tissues including kidney, lung.

The current experiments were designed to determine the role that cyclooxygenase- and lipoxygenase-derived mediators play in the lung injury caused by t-bu-OOH. The role of cyclooxygenase and lipoxygenase mediators in oxidant-induced lung injury. / Farrukh, I G. / The role of cyclooxygenase and lipoxygenase mediators in oxidant.

Unlike COX and lipoxygenase products, the roles of CYP pathways in the immune response are poorly understood. CYPs metabolise arachidonic acid by: i) epoxygenases that catalyze arachidonic acid to epoxyeicosatrienoic acids (EETs); ii) the lipoxygenase-like CYPs; and iii) the ω- and ωhydroxylase CYPs which produce hydroxyeicosatetraenoic.

The administration of monocrotaline is apparently followed by an increased lung tissue production of cyclooxygenase and lipoxygenase metabolites, 38 x 38 Stenmark, KR, Morganroth, ML, Remigio, LK, Voelkel, NF, Murphy, RC, Henson, PM et al. Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension.Cathcart, Mary-Clare, O'Byrne, Kenneth, & Pidgeon, Graham () The role of the arachidonic acid signalling pathway in NSCLC development and progression: novel targets for therapeutic intervention.

In Gately, K (Ed.) Lung cancer: a comprehensive overview. Nova Science Publishers, United States, pp.

.In this article we will review evidence of COX-2 and 5-LO involvement in cancer pathobiology, propose a model of integrated control of cell proliferation by these enzymes, and discuss the pharmacologic implications of this model.—Romano, M., Clària, J.

Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor.